/*
  Eleven Therapeutics | 核酸航图
  Contemporary Scientific Editorial Design：深井墨蓝、核苷酸青绿、非对称研究航图与克制的仪器感动态。
*/

:root {
  --ink: #061923;
  --ink-soft: #0a2430;
  --ink-raised: #0d2b37;
  --paper: #f3f3ed;
  --paper-deep: #d7d9d2;
  --teal: #55e6c1;
  --teal-dim: #2c9e86;
  --teal-wash: rgba(85, 230, 193, 0.12);
  --line: rgba(224, 244, 237, 0.2);
  --line-strong: rgba(224, 244, 237, 0.42);
  --muted: #aebcbb;
  --font-display: "DM Serif Display", Georgia, serif;
  --font-body: "Manrope", Arial, sans-serif;
  --font-mono: "IBM Plex Mono", monospace;
  --ease-out: cubic-bezier(0.23, 1, 0.32, 1);
}

* { box-sizing: border-box; }

html { scroll-behavior: smooth; }

body {
  margin: 0;
  min-width: 320px;
  color: var(--paper);
  background: var(--ink);
  font-family: var(--font-body);
  -webkit-font-smoothing: antialiased;
  text-rendering: optimizeLegibility;
}

body.menu-open { overflow: hidden; }

a { color: inherit; text-decoration: none; }

button { font: inherit; }

::selection { color: var(--ink); background: var(--teal); }

.site-shell {
  position: relative;
  overflow: clip;
}

.site-shell::before {
  position: fixed;
  z-index: 20;
  top: 0;
  left: 0;
  width: var(--scroll-progress, 0%);
  height: 2px;
  content: "";
  background: var(--teal);
  box-shadow: 0 0 18px rgba(85, 230, 193, 0.75);
}

.site-shell::after {
  position: fixed;
  z-index: -1;
  inset: 0;
  content: "";
  pointer-events: none;
  opacity: 0.32;
  background-image: radial-gradient(rgba(255,255,255,0.3) 0.5px, transparent 0.6px);
  background-size: 7px 7px;
  mix-blend-mode: soft-light;
}

.rail {
  position: absolute;
  z-index: 1;
  top: 96px;
  bottom: 0;
  left: clamp(20px, 6vw, 92px);
  width: 1px;
  background: linear-gradient(var(--line-strong) 0 78%, transparent 100%);
}

.rail::after {
  position: sticky;
  top: 128px;
  display: block;
  width: 7px;
  height: 7px;
  margin-left: -3px;
  content: "";
  border: 1px solid var(--teal);
  border-radius: 50%;
  background: var(--ink);
  box-shadow: 0 0 0 5px rgba(85,230,193,0.08);
}

.site-header {
  position: fixed;
  z-index: 10;
  top: 0;
  right: 0;
  left: 0;
  height: 88px;
  border-bottom: 1px solid transparent;
  transition: background-color 220ms var(--ease-out), border-color 220ms var(--ease-out), backdrop-filter 220ms var(--ease-out);
}

.site-header.scrolled {
  border-color: rgba(225, 244, 238, 0.12);
  background: rgba(6, 25, 35, 0.84);
  backdrop-filter: blur(14px);
}

.nav-wrap {
  display: grid;
  grid-template-columns: minmax(230px, 1fr) auto minmax(230px, 1fr);
  align-items: center;
  width: min(100% - 48px, 1400px);
  height: 100%;
  margin: 0 auto;
}

.brand {
  display: inline-flex;
  gap: 11px;
  align-items: center;
  width: max-content;
}

.brand img { width: 34px; height: 34px; object-fit: contain; }

.brand-lockup { display: grid; gap: 2px; }

.brand-wordmark {
  color: var(--paper);
  font-family: var(--font-display);
  font-size: 19px;
  font-weight: 400;
  line-height: 0.9;
  letter-spacing: -0.03em;
}

.brand-subtitle,
.eyebrow,
.side-index,
.micro-label,
.stat-label,
.footer-label,
.protocol-label {
  font-family: var(--font-mono);
  font-size: 10px;
  font-weight: 500;
  line-height: 1.2;
  letter-spacing: 0.13em;
  text-transform: uppercase;
}

.brand-subtitle { color: var(--muted); font-size: 8px; letter-spacing: 0.19em; }

.desktop-nav { display: flex; gap: clamp(17px, 2vw, 32px); align-items: center; }

.desktop-nav a {
  position: relative;
  color: rgba(243, 243, 237, 0.72);
  font-family: var(--font-mono);
  font-size: 10px;
  letter-spacing: 0.09em;
  text-transform: uppercase;
  transition: color 180ms var(--ease-out);
}

.desktop-nav a::after {
  position: absolute;
  right: 0;
  bottom: -9px;
  left: 0;
  height: 1px;
  content: "";
  background: var(--teal);
  transform: scaleX(0);
  transform-origin: right;
  transition: transform 180ms var(--ease-out);
}

.desktop-nav a:hover, .desktop-nav a.is-active { color: var(--paper); }
.desktop-nav a:hover::after, .desktop-nav a.is-active::after { transform: scaleX(1); transform-origin: left; }

.nav-cta, .button-primary, .button-quiet {
  display: inline-flex;
  gap: 10px;
  align-items: center;
  justify-content: center;
  min-height: 43px;
  border: 1px solid var(--teal);
  color: var(--ink);
  background: var(--teal);
  font-family: var(--font-mono);
  font-size: 10px;
  font-weight: 600;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  transition: transform 160ms var(--ease-out), background-color 180ms var(--ease-out), color 180ms var(--ease-out);
}

.nav-cta { justify-self: end; padding: 0 17px; }
.nav-cta:hover, .button-primary:hover { background: transparent; color: var(--teal); }
.nav-cta:active, .button-primary:active, .button-quiet:active { transform: scale(0.97); }

.nav-toggle {
  display: none;
  justify-self: end;
  width: 40px;
  height: 40px;
  border: 0;
  color: var(--paper);
  background: transparent;
}

.nav-toggle span { display: block; width: 24px; height: 1px; margin: 5px auto; background: currentColor; transition: transform 180ms var(--ease-out), opacity 180ms var(--ease-out); }
.nav-toggle[aria-expanded="true"] span:first-child { transform: translateY(6px) rotate(45deg); }
.nav-toggle[aria-expanded="true"] span:nth-child(2) { opacity: 0; }
.nav-toggle[aria-expanded="true"] span:last-child { transform: translateY(-6px) rotate(-45deg); }

.mobile-nav {
  position: fixed;
  z-index: 9;
  inset: 88px 0 0;
  display: grid;
  align-content: start;
  gap: 22px;
  padding: 44px 24px;
  visibility: hidden;
  opacity: 0;
  background: rgba(6, 25, 35, 0.98);
  transform: translateY(-12px);
  transition: visibility 0s 220ms, opacity 220ms var(--ease-out), transform 220ms var(--ease-out);
}

.mobile-nav.open { visibility: visible; opacity: 1; transform: translateY(0); transition: visibility 0s, opacity 220ms var(--ease-out), transform 220ms var(--ease-out); }
.mobile-nav a { color: var(--paper); font-family: var(--font-display); font-size: 42px; letter-spacing: -0.04em; }
.mobile-nav .button-primary { width: max-content; padding: 0 18px; margin-top: 14px; }

.hero {
  position: relative;
  display: grid;
  grid-template-columns: minmax(0, 1.05fr) minmax(420px, 0.95fr);
  min-height: min(900px, 100svh);
  padding: 162px max(7.5vw, 72px) 64px max(11vw, 118px);
  isolation: isolate;
}

.hero::before {
  position: absolute;
  z-index: -2;
  inset: 0;
  content: "";
  background: linear-gradient(90deg, #061923 0%, rgba(6,25,35,0.98) 43%, rgba(6,25,35,0.38) 71%, rgba(6,25,35,0.1) 100%);
}

.hero-art {
  position: absolute;
  z-index: -3;
  inset: 0;
  width: 100%;
  height: 100%;
  object-fit: cover;
  object-position: center;
  opacity: 0.9;
}

.hero-copy { align-self: center; max-width: 750px; padding-bottom: 44px; }

.eyebrow { display: flex; gap: 11px; align-items: center; color: var(--teal); }
.eyebrow::before { width: 32px; height: 1px; content: ""; background: currentColor; }

.hero h1, .section-title, .statement { margin: 0; font-family: var(--font-display); font-weight: 400; letter-spacing: -0.058em; }

.hero h1 { max-width: 750px; margin-top: 24px; font-size: clamp(54px, 6.35vw, 101px); line-height: 0.92; }
.hero h1 em { color: var(--teal); font-style: italic; }

.hero-dek { max-width: 550px; margin: 32px 0 0; color: var(--paper-deep); font-size: 16px; line-height: 1.76; }

.hero-actions { display: flex; flex-wrap: wrap; gap: 16px; margin-top: 36px; }
.button-primary { padding: 0 20px; }
.button-primary svg, .button-quiet svg { width: 14px; height: 14px; transition: transform 180ms var(--ease-out); }
.button-primary:hover svg, .button-quiet:hover svg { transform: translateX(3px); }

.button-quiet { padding: 0 12px; border-color: transparent; color: var(--paper); background: transparent; }
.button-quiet:hover { color: var(--teal); }

.hero-meta {
  position: absolute;
  right: max(7.5vw, 72px);
  bottom: 66px;
  display: grid;
  grid-template-columns: auto auto;
  gap: 22px 40px;
  align-items: end;
  color: var(--paper);
}

.hero-meta::before { grid-column: 1 / -1; width: 100%; height: 1px; content: ""; background: var(--line); }
.hero-meta div { display: grid; gap: 7px; }
.hero-meta strong { color: var(--teal); font-family: var(--font-display); font-size: 26px; font-weight: 400; line-height: 1; }
.hero-meta span { color: var(--muted); font-family: var(--font-mono); font-size: 9px; letter-spacing: 0.1em; text-transform: uppercase; }

.section {
  position: relative;
  z-index: 2;
  padding: 154px max(7.5vw, 72px) 154px max(11vw, 118px);
  scroll-margin-top: 84px;
}

.section-top { display: grid; grid-template-columns: 1fr minmax(210px, 0.34fr); gap: 48px; align-items: end; }
.side-index { color: var(--teal); }
.side-index span { display: block; margin-bottom: 14px; color: var(--muted); }
.section-title { max-width: 900px; font-size: clamp(41px, 5.1vw, 76px); line-height: 0.97; }
.section-title em { color: var(--teal); font-style: italic; }
.section-intro { max-width: 310px; margin: 0; color: var(--muted); font-size: 14px; line-height: 1.75; }

.platform { background: var(--paper); color: var(--ink); }
.platform::after { position: absolute; z-index: -1; top: 0; right: 0; width: min(48vw, 720px); height: 100%; content: ""; opacity: 0.22; background-image: radial-gradient(circle at 29% 25%, #0c7b68 0 2px, transparent 2.5px), radial-gradient(circle at 66% 32%, #0c7b68 0 1px, transparent 1.5px), radial-gradient(circle at 75% 68%, #0c7b68 0 3px, transparent 3.5px), linear-gradient(126deg, transparent 26%, rgba(12,123,104,0.38) 26.2%, transparent 26.5%), linear-gradient(41deg, transparent 44%, rgba(12,123,104,0.3) 44.2%, transparent 44.5%), repeating-linear-gradient(90deg, transparent 0 47px, rgba(12,123,104,0.15) 47px 48px); background-size: 165px 150px, 224px 204px, 290px 260px, 410px 320px, 550px 410px, auto; }
.platform .section-intro { color: #41605e; }
.platform .side-index { color: #0c7b68; }
.platform .side-index span { color: #667c78; }

.process-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 0; margin-top: 92px; border-top: 1px solid rgba(6,25,35,0.24); }
.process-card { position: relative; min-height: 350px; padding: 31px 30px 28px 0; border-right: 1px solid rgba(6,25,35,0.24); }
.process-card + .process-card { padding-left: 30px; }
.process-card:last-child { border-right: 0; }
.process-number { display: block; margin-bottom: 74px; color: #0c7b68; font-family: var(--font-mono); font-size: 11px; letter-spacing: 0.11em; }
.process-card h3 { max-width: 240px; margin: 0; font-family: var(--font-display); font-size: 35px; font-weight: 400; line-height: 1; letter-spacing: -0.045em; }
.process-card p { max-width: 270px; margin: 20px 0 0; color: #41605e; font-size: 14px; line-height: 1.75; }
.process-marker { position: absolute; bottom: 29px; left: 0; width: 11px; height: 11px; border: 1px solid #0c7b68; border-radius: 50%; background: var(--paper); }
.process-card + .process-card .process-marker { left: 30px; }
.process-card:last-child .process-marker { background: #0c7b68; box-shadow: 0 0 0 5px rgba(12,123,104,0.12); }

.molecule { padding-top: 0; background: var(--ink); }
.molecule-grid { display: grid; grid-template-columns: minmax(260px, 0.74fr) minmax(0, 1.18fr); gap: clamp(48px, 9vw, 156px); align-items: center; }
.molecule-visual { position: relative; min-height: 600px; overflow: hidden; }
.molecule-visual::before { position: absolute; z-index: 1; top: 22px; right: 25px; width: 45px; height: 45px; content: ""; border: 1px solid var(--teal); border-radius: 50%; background: var(--ink); box-shadow: 0 0 0 10px rgba(85,230,193,0.05); }
.molecule-art { position: relative; min-height: 600px; overflow: hidden; background: radial-gradient(circle at 52% 40%, rgba(85,230,193,0.13), transparent 32%), linear-gradient(152deg, #0b2935 0%, #061923 67%); }
.molecule-art::before, .molecule-art::after { position: absolute; content: ""; pointer-events: none; }
.molecule-art::before { inset: 13% 13%; border: 1px solid rgba(85,230,193,0.22); border-radius: 46% 54% 54% 46% / 37% 41% 59% 63%; transform: rotate(-24deg); box-shadow: 0 0 0 52px rgba(85,230,193,0.022), 0 0 0 112px rgba(85,230,193,0.015); }
.molecule-art::after { top: -3%; left: 38%; width: 2px; height: 110%; background: linear-gradient(transparent, rgba(85,230,193,0.7) 17%, rgba(238,244,238,0.7) 42%, rgba(85,230,193,0.8) 67%, transparent); transform: rotate(28deg); box-shadow: 67px 0 0 rgba(238,244,238,0.3), -65px 0 0 rgba(85,230,193,0.25); }
.rna-strand { position: absolute; z-index: 1; display: block; width: 68%; height: 30px; border: 1px solid rgba(242,244,238,0.68); border-left: 0; border-radius: 50%; filter: drop-shadow(0 0 8px rgba(85,230,193,0.16)); }
.rna-strand::after { position: absolute; top: 50%; left: 22%; width: 11px; height: 11px; content: ""; border: 1px solid var(--teal); border-radius: 50%; background: var(--ink); box-shadow: 84px -4px 0 -1px var(--ink), 84px -4px 0 0 var(--teal), 165px 1px 0 -1px var(--ink), 165px 1px 0 0 var(--teal); }
.rna-strand:nth-child(1) { top: 17%; left: 7%; transform: rotate(30deg); }
.rna-strand:nth-child(2) { top: 28%; right: -8%; border-color: rgba(85,230,193,0.8); transform: rotate(-37deg); }
.rna-strand:nth-child(3) { top: 42%; left: -8%; transform: rotate(39deg); }
.rna-strand:nth-child(4) { top: 56%; right: -8%; border-color: rgba(85,230,193,0.75); transform: rotate(-29deg); }
.rna-strand:nth-child(5) { top: 69%; left: 8%; transform: rotate(33deg); }
.rna-strand:nth-child(6) { top: 79%; right: -4%; border-color: rgba(85,230,193,0.78); transform: rotate(-35deg); }
.image-caption { position: absolute; z-index: 2; right: 0; bottom: 24px; left: 0; display: flex; justify-content: space-between; padding: 16px 19px; border-top: 1px solid var(--line); color: var(--muted); background: rgba(6,25,35,0.62); font-family: var(--font-mono); font-size: 9px; letter-spacing: 0.08em; text-transform: uppercase; backdrop-filter: blur(8px); }
.molecule-copy { max-width: 640px; padding-top: 94px; }
.molecule-copy .section-title { margin-top: 22px; }
.molecule-copy > p { max-width: 525px; margin: 27px 0 0; color: var(--paper-deep); font-size: 16px; line-height: 1.75; }

.feature-list { margin-top: 45px; border-top: 1px solid var(--line); }
.feature-list article { display: grid; grid-template-columns: 34px 1fr auto; gap: 18px; align-items: center; min-height: 70px; border-bottom: 1px solid var(--line); }
.feature-list span { color: var(--teal); font-family: var(--font-mono); font-size: 10px; }
.feature-list h3 { margin: 0; font-family: var(--font-body); font-size: 13px; font-weight: 600; letter-spacing: 0.01em; }
.feature-list p { max-width: 200px; margin: 0; color: var(--muted); font-size: 11px; line-height: 1.5; text-align: right; }

.pipeline { background: #09202c; }
.pipeline .section-top { grid-template-columns: minmax(0, 1fr) minmax(250px, 0.55fr); }
.pipeline-chart { position: relative; display: grid; grid-template-columns: 1.18fr 0.9fr 0.72fr 0.72fr; gap: 12px; align-items: end; min-height: 390px; margin-top: 85px; padding: 44px 0 0; border-top: 1px solid var(--line); }
.pipeline-chart::before { position: absolute; top: 44px; right: 0; left: 0; height: 1px; content: ""; background: linear-gradient(90deg, var(--teal), var(--line) 58%, transparent 58%); }
.program { position: relative; display: grid; align-content: space-between; min-height: 260px; padding: 17px 19px; border: 1px solid var(--line); background: rgba(6,25,35,0.46); transition: transform 200ms var(--ease-out), border-color 200ms var(--ease-out); }
.program:hover { border-color: var(--teal); transform: translateY(-6px); }
.program::before { position: absolute; top: -50px; left: 0; width: 1px; height: 50px; content: ""; background: var(--line-strong); }
.program:first-child::before { background: var(--teal); }
.program-stage { color: var(--teal); font-family: var(--font-mono); font-size: 9px; letter-spacing: 0.12em; text-transform: uppercase; }
.program h3 { margin: 0; font-family: var(--font-display); font-size: 29px; font-weight: 400; line-height: 0.98; letter-spacing: -0.04em; }
.program p { margin: 13px 0 0; color: var(--muted); font-size: 12px; line-height: 1.6; }
.program-status { display: flex; gap: 8px; align-items: center; color: var(--paper-deep); font-family: var(--font-mono); font-size: 9px; letter-spacing: 0.09em; text-transform: uppercase; }
.program-status::before { width: 6px; height: 6px; content: ""; border-radius: 50%; background: var(--teal); box-shadow: 0 0 0 4px rgba(85,230,193,0.1); }
.program.is-quiet .program-status::before { background: transparent; border: 1px solid var(--muted); box-shadow: none; }
.program:nth-child(2) { min-height: 232px; }
.program:nth-child(3) { min-height: 202px; }
.program:nth-child(4) { min-height: 175px; }

.science { padding-bottom: 132px; background: var(--paper); color: var(--ink); }
.science .section-intro { color: #41605e; }
.science .side-index { color: #0c7b68; }
.science .side-index span { color: #667c78; }
.science-statement { display: grid; grid-template-columns: minmax(0, 1.2fr) 0.65fr; gap: 68px; align-items: end; margin-top: 95px; padding-top: 32px; border-top: 1px solid rgba(6,25,35,0.2); }
.statement { max-width: 840px; font-size: clamp(41px, 5vw, 72px); line-height: 0.99; }
.statement span { color: #0c7b68; font-style: italic; }
.science-note { margin: 0; padding-left: 23px; border-left: 1px solid #0c7b68; color: #41605e; font-size: 14px; line-height: 1.75; }
.science-link { display: inline-flex; gap: 11px; align-items: center; margin-top: 42px; color: #0c7b68; font-family: var(--font-mono); font-size: 10px; font-weight: 600; letter-spacing: 0.11em; text-transform: uppercase; }
.science-link::after { width: 27px; height: 1px; content: ""; background: currentColor; transition: width 180ms var(--ease-out); }
.science-link:hover::after { width: 45px; }

.contact { position: relative; padding-top: 162px; padding-bottom: 115px; background: var(--ink); isolation: isolate; }
.contact::before { position: absolute; z-index: -2; inset: 0; content: ""; opacity: 0.48; background-image: radial-gradient(circle at 7% 65%, rgba(85,230,193,0.72) 0 1px, transparent 1.5px), radial-gradient(circle at 58% 18%, rgba(85,230,193,0.52) 0 1px, transparent 1.5px), repeating-linear-gradient(118deg, transparent 0 50px, rgba(85,230,193,0.12) 50px 51px, transparent 51px 87px), linear-gradient(90deg, var(--ink) 5%, rgba(6,25,35,0.44) 85%); background-size: 122px 117px, 197px 171px, 340px 340px, auto; }
.contact-grid { display: grid; grid-template-columns: minmax(0, 1.25fr) minmax(240px, 0.6fr); gap: 68px; align-items: end; }
.contact h2 { max-width: 820px; margin: 20px 0 0; font-family: var(--font-display); font-size: clamp(48px, 6.2vw, 90px); font-weight: 400; line-height: 0.94; letter-spacing: -0.06em; }
.contact h2 em { color: var(--teal); font-style: italic; }
.contact-card { padding: 28px; border: 1px solid var(--line); background: rgba(10,36,48,0.66); backdrop-filter: blur(12px); }
.contact-card p { margin: 18px 0 22px; color: var(--paper-deep); font-size: 14px; line-height: 1.7; }
.contact-card a { display: inline-flex; gap: 11px; align-items: center; color: var(--teal); font-family: var(--font-mono); font-size: 10px; font-weight: 600; letter-spacing: 0.1em; text-transform: uppercase; }

.site-footer { display: grid; grid-template-columns: 1fr auto 1fr; gap: 20px; align-items: end; padding: 33px max(7.5vw, 72px) 42px max(11vw, 118px); border-top: 1px solid var(--line); background: var(--ink); }
.footer-copy { margin: 0; color: var(--muted); font-family: var(--font-mono); font-size: 9px; letter-spacing: 0.07em; text-transform: uppercase; }
.footer-center { color: var(--paper); font-family: var(--font-display); font-size: 17px; }
.footer-links { display: flex; gap: 18px; justify-self: end; color: var(--muted); font-family: var(--font-mono); font-size: 9px; letter-spacing: 0.08em; text-transform: uppercase; }
.footer-links a:hover { color: var(--teal); }

.reveal { opacity: 0; transform: translateY(14px); transition: opacity 600ms var(--ease-out), transform 600ms var(--ease-out); }
.reveal.in-view { opacity: 1; transform: translateY(0); }
.reveal-delay-1 { transition-delay: 60ms; }
.reveal-delay-2 { transition-delay: 120ms; }

@media (prefers-reduced-motion: no-preference) {
  .hero-art { animation: drift 12s ease-in-out infinite alternate; }
  .molecule-visual::before { animation: pulse 3.5s ease-in-out infinite; }
}

@keyframes drift { from { transform: scale(1.01); } to { transform: scale(1.05) translateX(-0.45%); } }
@keyframes pulse { 0%, 100% { box-shadow: 0 0 0 10px rgba(85,230,193,0.05); } 50% { box-shadow: 0 0 0 17px rgba(85,230,193,0.01); } }

@media (max-width: 960px) {
  .nav-wrap { grid-template-columns: 1fr auto; width: min(100% - 40px, 1400px); }
  .desktop-nav, .nav-cta { display: none; }
  .nav-toggle { display: block; }
  .hero { grid-template-columns: 1fr; min-height: 790px; padding: 148px 44px 60px 84px; }
  .hero::before { background: linear-gradient(90deg, rgba(6,25,35,0.96) 0%, rgba(6,25,35,0.86) 53%, rgba(6,25,35,0.44) 100%); }
  .hero-meta { right: 44px; }
  .section { padding: 118px 44px 118px 84px; }
  .section-top { grid-template-columns: 1fr; gap: 22px; }
  .section-intro { max-width: 470px; }
  .process-grid { margin-top: 64px; }
  .process-card { min-height: 335px; }
  .molecule-grid { grid-template-columns: 0.88fr 1fr; gap: 46px; }
  .molecule-visual, .molecule-art { min-height: 530px; }
  .feature-list article { grid-template-columns: 27px 1fr; padding: 14px 0; }
  .feature-list p { grid-column: 2; max-width: none; text-align: left; }
  .pipeline-chart { grid-template-columns: 1fr 1fr; }
  .science-statement, .contact-grid { grid-template-columns: 1fr; gap: 38px; }
  .site-footer { grid-template-columns: 1fr auto; padding: 30px 44px 36px 84px; }
  .footer-center { display: none; }
}

@media (max-width: 640px) {
  .rail { left: 22px; }
  .site-header { height: 74px; }
  .nav-wrap { width: min(100% - 32px, 1400px); }
  .brand img { width: 31px; height: 31px; }
  .brand-wordmark { font-size: 18px; }
  .mobile-nav { inset: 74px 0 0; }
  .hero { min-height: 760px; padding: 127px 24px 42px 48px; }
  .hero::before { background: linear-gradient(90deg, rgba(6,25,35,0.98) 0%, rgba(6,25,35,0.84) 80%, rgba(6,25,35,0.54) 100%); }
  .hero h1 { font-size: clamp(48px, 14.2vw, 72px); }
  .hero-dek { margin-top: 24px; font-size: 14px; }
  .hero-actions { gap: 9px; margin-top: 29px; }
  .hero-meta { right: 24px; bottom: 31px; gap: 16px 26px; }
  .hero-meta strong { font-size: 23px; }
  .section { padding: 92px 24px 92px 48px; }
  .section-title { font-size: clamp(40px, 12vw, 62px); }
  .platform::after { width: 100%; opacity: 0.08; }
  .process-grid { grid-template-columns: 1fr; margin-top: 54px; }
  .process-card, .process-card + .process-card { min-height: 245px; padding: 26px 0; border-right: 0; border-bottom: 1px solid rgba(6,25,35,0.24); }
  .process-number { margin-bottom: 34px; }
  .process-marker, .process-card + .process-card .process-marker { bottom: -6px; left: 0; }
  .molecule { padding-top: 0; }
  .molecule-grid { grid-template-columns: 1fr; gap: 0; }
  .molecule-visual, .molecule-art { min-height: 440px; }
  .molecule-copy { padding-top: 64px; }
  .pipeline-chart { grid-template-columns: 1fr; min-height: 0; margin-top: 58px; padding-top: 41px; }
  .program, .program:nth-child(2), .program:nth-child(3), .program:nth-child(4) { min-height: 183px; }
  .science-statement { margin-top: 58px; }
  .statement { font-size: clamp(39px, 11.4vw, 56px); }
  .contact { padding-top: 104px; padding-bottom: 70px; }
  .contact h2 { font-size: clamp(51px, 14.2vw, 74px); }
  .site-footer { grid-template-columns: 1fr; gap: 20px; padding: 27px 24px 33px 48px; }
  .footer-links { justify-self: start; }
}

@media (prefers-reduced-motion: reduce) {
  *, *::before, *::after { scroll-behavior: auto !important; animation-duration: 0.01ms !important; animation-iteration-count: 1 !important; transition-duration: 0.01ms !important; }
}