Abstract programmable RNA molecule and scientific trajectory map

Discovery, written in RNA

A more programmable path to RNAi medicines.

Eleven Therapeutics unites artificial intelligence, parallel functional testing, and combinatorial chemistry to create a new generation of medicinal nucleic acids.

AIDesign intelligence
RNAiProgrammable modality

01 / PlatformFrom hypothesis
to a functional signal.

One platform.
Many paths to precision.

Our discovery engine turns biological complexity into an integrated, experimentally grounded search space.

01 / INFER

Artificial intelligence

Model the sequence, chemistry and target interactions that shape therapeutic potential.

02 / TEST

Parallel functional testing

Measure a broad design space directly in relevant functional assays, rather than relying on proxy signals.

03 / REFINE

Combinatorial chemistry

Advance the molecular architectures that bring performance, precision and programmability into focus.

Structure / SCSIProgrammable molecule

02 / SCSI-RNAA programmable molecular architecture.

Designed to reach the targets that matter.

SCSI-RNA is a programmable molecule built to target diseases and biological targets of interest. It represents a new design space for RNA interference—one where chemical architecture and functional performance are developed together.

01

Sequence-addressable

Built around the biology of the selected target.

02

Functionally tested

Validated through parallel experimental evidence.

03

Chemically configurable

Refined across a wider therapeutic design space.

03 / PipelinePrograms engineered around biological opportunity.

A discovery engine made to expand the addressable.

We are building a platform capable of opening differentiated paths across diseases where precisely designed nucleic acids can create new therapeutic options.

Discovery

Target
definition

Computational and biological model building.

Active design space
Optimization

Functional
selection

Parallel test-and-learn cycles.

Active design space
Translation

Candidate
nomination

Molecular attributes aligned to development needs.

Programmed next step
Development

Clinical
possibility

Advancing medicines with a clearer molecular rationale.

Programmed next step

04 / ScienceEvidence is our operating system.

A technology platform is only as good as the questions it can answer.

We use computation to widen inquiry—and functional evidence to make the decision. The goal is not more designs. It is more informative designs.

We design with biology, not around it.

By merging model-driven iteration with parallel functional testing, Eleven Therapeutics seeks to make medicinal nucleic acid discovery more legible, more predictive and more adaptable.

Start a scientific conversation

Partnering & inquiry

New medicines begin with a better question.